Polymorphic substitution E157Q in HIV-1 integrase increases R263K-mediated dolutegravir resistance and decreases DNA binding activity

OBJECTIVES: The E157Q substitution in HIV-1 integrase (IN) is a relatively common natural polymorphism associated with HIV resistance to IN strand transfer inhibitors (INSTIs). Although R263K is the most common resistance substitution for the INSTI dolutegravir, an INSTI treatment-experienced indivi...

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Detalles Bibliográficos
Publicado en:J Antimicrob Chemother
Main Authors: Anstett, Kaitlin, Cutillas, Vincent, Fusco, Robert, Mesplède, Thibault, Wainberg, Mark A.
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2016
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Original Research
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4954922/
https://ncbi.nlm.nih.gov/pubmed/27084918
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jac/dkw109
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