The unfolded protein response genes in human osteoarthritic chondrocytes: PERK emerges as a potential therapeutic target

BACKGROUND: The unfolded protein response (UPR) is activated following an endoplasmic reticulum (ER) stress. The aim of this study was to investigate the global expression of UPR genes in human OA chondrocytes in induced (I)-UPR conditions, and to explore the regulation and role of the UPR genes in...

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Detalhes bibliográficos
Publicado no:Arthritis Res Ther
Main Authors: Li, Ying-Hua, Tardif, Ginette, Hum, David, Kapoor, Mohit, Fahmi, Hassan, Pelletier, Jean-Pierre, Martel-Pelletier, Johanne
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4952234/
https://ncbi.nlm.nih.gov/pubmed/27435272
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13075-016-1070-6
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