Regulation of the IGFBP-5 and MMP-13 genes by the microRNAs miR-140 and miR-27a in human osteoarthritic chondrocytes

BACKGROUND: MMP-13 and IGFBP-5 are important factors involved in osteoarthritis (OA). We investigated whether two highly predicted microRNAs (miRNAs), miR-140 and miR-27a, regulate these two genes in human OA chondrocytes. METHODS: Gene expression was determined by real-time PCR. The effect of each...

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Autores principales: Tardif, Ginette, Hum, David, Pelletier, Jean-Pierre, Duval, Nicolas, Martel-Pelletier, Johanne
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2009
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Research article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2792220/
https://ncbi.nlm.nih.gov/pubmed/19948051
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2474-10-148
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