Lysine-specific demethylase 1-mediated demethylation of histone H3 lysine 9 contributes to interleukin 1β-induced microsomal prostaglandin E synthase 1 expression in human osteoarthritic chondrocytes

INTRODUCTION: Microsomal prostaglandin E synthase 1 (mPGES-1) catalyzes the terminal step in the biosynthesis of PGE(2), a critical mediator in the pathophysiology of osteoarthritis (OA). Histone methylation plays an important role in epigenetic gene regulation. In this study, we investigated the ro...

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Hlavní autoři: El Mansouri, Fatima Ezzahra, Nebbaki, Salwa-Sarah, Kapoor, Mohit, Afif, Hassan, Martel-Pelletier, Johanne, Pelletier, Jean-Pierre, Benderdour, Mohamed, Fahmi, Hassan
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2014
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4060543/
https://ncbi.nlm.nih.gov/pubmed/24886859
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/ar4564
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