Egr-1 contributes to IL-1-mediated down-regulation of peroxisome proliferator-activated receptor γ expression in human osteoarthritic chondrocytes

INTRODUCTION: Peroxisome proliferator-activated receptor (PPAR)γ has been shown to exhibit anti-inflammatory and anti-catabolic properties and to be protective in animal models of osteoarthritis (OA). We have previously shown that interleukin-1β (IL-1) down-regulates PPARγ expression in human OA cho...

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Hauptverfasser: Nebbaki, Sarah-Salwa, El Mansouri, Fatima Ezzahra, Afif, Hassan, Kapoor, Mohit, Benderdour, Mohamed, Duval, Nicolas, Pelletier, Jean-Pierre, Martel-Pelletier, Johanne, Fahmi, Hassan
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2012
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3446440/
https://ncbi.nlm.nih.gov/pubmed/22455954
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/ar3788
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