PTBP1-associated microRNA-1 and -133b suppress the Warburg effect in colorectal tumors

It is known that pyruvate kinase in muscle (PKM), which is a rate-limiting glycolytic enzyme, has essential roles in the Warburg effect and that expression of cancer-dominant PKM2 is increased by polypyrimidine tract-binding protein 1 (PTBP1), which is a splicer of the PKM gene. In other words, PKM2...

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Vydáno v:Oncotarget
Hlavní autoři: Taniguchi, Kohei, Sakai, Miku, Sugito, Nobuhiko, Kumazaki, Minami, Shinohara, Haruka, Yamada, Nami, Nakayama, Tatsushi, Ueda, Hiroshi, Nakagawa, Yoshihito, Ito, Yuko, Futamura, Manabu, Uno, Bunji, Otsuki, Yoshinori, Yoshida, Kazuhiro, Uchiyama, Kazuhisa, Akao, Yukihiro
Médium: Artigo
Jazyk:Inglês
Vydáno: Impact Journals LLC 2016
Témata:
Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4951342/
https://ncbi.nlm.nih.gov/pubmed/26980745
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.8005
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