Organ-specific PTB1-associated microRNAs determine expression of pyruvate kinase isoforms

The Warburg effect is a well-known feature of cancer cells. However, its' functional significance hasn't been elucidated yet. Pyruvate kinase muscle (PKM), which is a rate-limiting glycolytic enzyme, has 2 isoforms, PKM1 and PKM2. It has been reported that PKM2 is a tumor-specific isoform...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Taniguchi, Kohei, Ito, Yuko, Sugito, Nobuhiko, Kumazaki, Minami, Shinohara, Haruka, Yamada, Nami, Nakagawa, Yoshihito, Sugiyama, Tarou, Futamura, Manabu, Otsuki, Yoshinori, Yoshida, Kazuhiro, Uchiyama, Kazuhisa, Akao, Yukihiro
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4342556/
https://ncbi.nlm.nih.gov/pubmed/25721733
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep08647
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