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SIRT2 inhibits non-small cell lung cancer cell growth through impairing Skp2-mediated p27 degradation
Skp2 is a component of the E3 ubiquitin ligase which promotes the ubiquitination-associated degradation of a cyclin-dependent kinase inhibitor, p27, resulting in increases in non-small cell lung cancer (NSCLC) cell growth. We recently showed that down-regulation of Sirtuin deacetylases 2 (SIRT2) in...
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| Pubblicato in: | Oncotarget |
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| Autori principali: | , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Impact Journals LLC
2016
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4951341/ https://ncbi.nlm.nih.gov/pubmed/26942878 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.7816 |
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