Dicer suppresses the malignant phenotype in VHL-deficient clear cell renal cell carcinoma by inhibiting HIF-2α

Both the von Hippel-Lindau (VHL)/hypoxia-inducible factor (HIF) pathway and microRNA (miRNA) regulation are important mechanisms underlying the development and progression of clear cell renal cell carcinoma (ccRCC). Here we demonstrate that VHL deficiency leads to downregulation of Dicer and, in tur...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Fan, Yang, Li, Hongzhao, Ma, Xin, Gao, Yu, Bao, Xu, Du, Qingshan, Ma, Minghui, Liu, Kan, Yao, Yuanxin, Huang, Qingbo, Zhang, Yu, Zhang, Xu
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2016
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4951288/
https://ncbi.nlm.nih.gov/pubmed/26943772
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.7807
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