Preclinical evaluation of biomarkers associated with antitumor activity of MELK inhibitor

MELK is upregulated in various types of human cancer and is known to be associated with cancer progression, maintenance of stemness, and poor prognosis. OTS167, a MELK kinase inhibitor, shows potent growth-suppressive effect on human tumors in a xenograft model, but the detailed mode of action has n...

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Bibliografiske detaljer
Udgivet i:Oncotarget
Main Authors: Chung, Suyoun, Kijima, Kyoko, Kudo, Aiko, Fujisawa, Yoshiko, Harada, Yosuke, Taira, Akiko, Takamatsu, Naofumi, Miyamoto, Takashi, Matsuo, Yo, Nakamura, Yusuke
Format: Artigo
Sprog:Inglês
Udgivet: Impact Journals LLC 2016
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4951280/
https://ncbi.nlm.nih.gov/pubmed/26918358
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.7685
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