Preclinical evaluation of biomarkers associated with antitumor activity of MELK inhibitor

MELK is upregulated in various types of human cancer and is known to be associated with cancer progression, maintenance of stemness, and poor prognosis. OTS167, a MELK kinase inhibitor, shows potent growth-suppressive effect on human tumors in a xenograft model, but the detailed mode of action has n...

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Библиографические подробности
Опубликовано в: :Oncotarget
Главные авторы: Chung, Suyoun, Kijima, Kyoko, Kudo, Aiko, Fujisawa, Yoshiko, Harada, Yosuke, Taira, Akiko, Takamatsu, Naofumi, Miyamoto, Takashi, Matsuo, Yo, Nakamura, Yusuke
Формат: Artigo
Язык:Inglês
Опубликовано: Impact Journals LLC 2016
Предметы:
Research Paper
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4951280/
https://ncbi.nlm.nih.gov/pubmed/26918358
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.7685
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