Development of novel SUV39H2 inhibitors that exhibit growth suppressive effects in mouse xenograft models and regulate the phosphorylation of H2AX

Protein methyltransferase SUV39H2 was reported to methylate histone H2AX at lysine 134 and enhance the formation of phosphorylated H2AX (γ-H2AX), which causes chemoresistance of cancer cells. We found that a series of imidazo[1,2-a]pyridine compounds that we synthesized could inhibit SUV39H2 methylt...

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Publicado en:Oncotarget
Autores principales: Vougiouklakis, Theodore, Saloura, Vassiliki, Park, Jae-Hyun, Takamatsu, Naofumi, Miyamoto, Takashi, Nakamura, Yusuke, Matsuo, Yo
Formato: Artigo
Lenguaje:Inglês
Publicado: Impact Journals LLC 2018
Materias:
Research Paper
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6112750/
https://ncbi.nlm.nih.gov/pubmed/30159125
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.25806
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