BRAF inhibitor resistance enhances vulnerability to arginine deprivation in melanoma

BRAF inhibitor (BRAFi) has been used for treatment of melanomas harboring V600E mutation. Despite a high initial response rate, resistance to BRAFi is inevitable. Here, we demonstrate that BRAFi-resistant (BR) melanomas are susceptible to arginine deprivation due to inability to initiate re-expressi...

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Detalles Bibliográficos
Publicado en:Oncotarget
Main Authors: Li, Ying-Ying, Wu, Chunjing, Chen, Shu-Mei, Shah, Sumedh S., Wangpaichitr, Medhi, Feun, Lynn G., Kuo, Macus T., Suarez, Miguel, Prince, Jeffrey, Savaraj, Niramol
Formato: Artigo
Idioma:Inglês
Publicado: Impact Journals LLC 2016
Assuntos:
Research Paper
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4951241/
https://ncbi.nlm.nih.gov/pubmed/26771234
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.6882
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