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Minireview: Genetic basis of heterogeneity and severity in sickle cell disease

Sickle cell disease, a common single gene disorder, has a complex pathophysiology that at its root is initiated by the polymerization of deoxy sickle hemoglobin. Sickle vasoocclusion and hemolytic anemia drive the development of disease complications. In this review, we focus on the genetic modifier...

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Detalhes bibliográficos
Publicado no:Exp Biol Med (Maywood)
Main Authors: Habara, Alawi, Steinberg, Martin H
Formato: Artigo
Idioma:Inglês
Publicado em: SAGE Publications 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4950383/
https://ncbi.nlm.nih.gov/pubmed/26936084
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/1535370216636726
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