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Mitochondrial and lysosomal biogenesis are activated following PINK1/parkin‐mediated mitophagy
Impairment of the autophagy–lysosome pathway is implicated with the changes in α‐synuclein and mitochondrial dysfunction observed in Parkinson's disease (PD). Damaged mitochondria accumulate PINK1, which then recruits parkin, resulting in ubiquitination of mitochondrial proteins. These can then...
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| Publicado en: | J Neurochem |
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| Autores principales: | , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
John Wiley and Sons Inc.
2015
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4949652/ https://ncbi.nlm.nih.gov/pubmed/26509433 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jnc.13412 |
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