Mitochondrial and lysosomal biogenesis are activated following PINK1/parkin‐mediated mitophagy

Impairment of the autophagy–lysosome pathway is implicated with the changes in α‐synuclein and mitochondrial dysfunction observed in Parkinson's disease (PD). Damaged mitochondria accumulate PINK1, which then recruits parkin, resulting in ubiquitination of mitochondrial proteins. These can then...

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Bibliografiske detaljer
Udgivet i:J Neurochem
Main Authors: Ivankovic, Davor, Chau, Kai‐Yin, Schapira, Anthony H. V., Gegg, Matthew E.
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2015
Fag:
ORIGINAL ARTICLES
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4949652/
https://ncbi.nlm.nih.gov/pubmed/26509433
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jnc.13412
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