CYP2D6 function moderates the pharmacokinetics and pharmacodynamics of 3,4-methylene-dioxymethamphetamine in a controlled study in healthy individuals

The role of genetic polymorphisms in cytochrome (CYP) 2D6 involved in the metabolism of 3,4-methylene-dioxymethamphetamine (MDMA, ecstasy) is unclear. Effects of genetic variants in CYP2D6 on the pharmacokinetics and pharmacodynamic effects of MDMA were characterized in 139 healthy individuals (70 m...

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Detalhes bibliográficos
Publicado no:Pharmacogenet Genomics
Main Authors: Schmid, Yasmin, Vizeli, Patrick, Hysek, Cédric M., Prestin, Katharina, Meyer zu Schwabedissen, Henriette E., Liechti, Matthias E.
Formato: Artigo
Idioma:Inglês
Publicado em: Lippincott Williams & Wilkins 2016
Assuntos:
Short Communication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4949007/
https://ncbi.nlm.nih.gov/pubmed/27253829
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/FPC.0000000000000231
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