Pharmacokinetics and Pharmacodynamics of Lisdexamfetamine Compared with D-Amphetamine in Healthy Subjects

Rationale: Lisdexamfetamine is a prodrug of D-amphetamine used for the treatment of attention-deficit/hyperactivity disorder (ADHD). Lisdexamfetamine is thought to have a prolonged pharmacokinetic profile compared with oral D-amphetamine, possibly associated with lower drug liking and a lower risk o...

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Main Authors: Patrick C. Dolder, Petra Strajhar, Patrick Vizeli, Felix Hammann, Alex Odermatt, Matthias E. Liechti
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2017-09-01
Colecção:Frontiers in Pharmacology
Assuntos:
D-amphetamine
lisdexamfetamine
subjective effects
autonomic effects
healthy subjects
Acesso em linha:http://journal.frontiersin.org/article/10.3389/fphar.2017.00617/full
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