Context Matters: Distinct Disease Outcomes as a Result of Crebbp Hemizygosity in Different Mouse Bone Marrow Compartments

Perturbations in CREB binding protein (CREBBP) are associated with hematopoietic malignancies, including myelodysplastic syndrome (MDS). Mice hemizygous for Crebbp develop myelodysplasia with proliferative features, reminiscent of human MDS/myeloproliferative neoplasm-unclassifiable (MDS/MPN-U), and...

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Publicado en:PLoS One
Autores principales: Zhou, Ting, Perez, Stephanie N., Cheng, Ziming, Kinney, Marsha C., Lemieux, Madeleine E., Scott, Linda M., Rebel, Vivienne I.
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2016
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4948888/
https://ncbi.nlm.nih.gov/pubmed/27427906
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0158649
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