Inactivation of a Single Copy of Crebbp Selectively Alters Pre-mRNA Processing in Mouse Hematopoietic Stem Cells

Global expression analysis of fetal liver hematopoietic stem cells (FL HSCs) revealed the presence of unspliced pre-mRNA for a number of genes in normal FL HSCs. In a subset of these genes, Crebbp+/− FL HSCs had less unprocessed pre-mRNA without a corresponding reduction in total mRNA levels. Among...

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Autori principali: Lemieux, Madeleine E., Cheng, Ziming, Zhou, Qing, White, Ruth, Cornell, John, Kung, Andrew L., Rebel, Vivienne I.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2011
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3162030/
https://ncbi.nlm.nih.gov/pubmed/21901164
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0024153
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