Context Matters: Distinct Disease Outcomes as a Result of Crebbp Hemizygosity in Different Mouse Bone Marrow Compartments

Perturbations in CREB binding protein (CREBBP) are associated with hematopoietic malignancies, including myelodysplastic syndrome (MDS). Mice hemizygous for Crebbp develop myelodysplasia with proliferative features, reminiscent of human MDS/myeloproliferative neoplasm-unclassifiable (MDS/MPN-U), and...

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Dettagli Bibliografici
Pubblicato in:PLoS One
Autori principali: Zhou, Ting, Perez, Stephanie N., Cheng, Ziming, Kinney, Marsha C., Lemieux, Madeleine E., Scott, Linda M., Rebel, Vivienne I.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2016
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4948888/
https://ncbi.nlm.nih.gov/pubmed/27427906
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0158649
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