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A MutSβ-Dependent Contribution of MutSα to Repeat Expansions in Fragile X Premutation Mice?
The fragile X-related disorders result from expansion of a CGG/CCG microsatellite in the 5’ UTR of the FMR1 gene. We have previously demonstrated that the MSH2/MSH3 complex, MutSβ, that is important for mismatch repair, is essential for almost all expansions in a mouse model of these disorders. Here...
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| Veröffentlicht in: | PLoS Genet |
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| Hauptverfasser: | , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Public Library of Science
2016
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4948851/ https://ncbi.nlm.nih.gov/pubmed/27427765 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1006190 |
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