Somatic expansion in mouse and human carriers of Fragile X premutation alleles

Repeat Expansion Diseases result from expansion of a specific tandem repeat. The three Fragile X-related disorders (FXDs) arise from germline expansions of a CGG•CCG repeat tract in the 5′ UTR of the FMR1 gene. We show here that in addition to germline expansion, expansion also occurs in the somatic...

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Bibliographic Details
Main Authors: Lokanga, Rachel Adihe, Entezam, Ali, Kumari, Daman, Yudkin, Dmitry, Qin, Mei, Smith, Carolyn Beebe, Usdin, Karen
Format: Artigo
Language:Inglês
Published: 2012
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3524353/
https://ncbi.nlm.nih.gov/pubmed/22887750
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/humu.22177
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