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Potassium bromate, a potent DNA oxidizing agent, exacerbates germline repeat expansion in a Fragile X premutation mouse model

Tandem repeat expansion is responsible for the Repeat Expansion Diseases, a group of human genetic disorders that includes Fragile X syndrome. FXS results from expansion of a premutation (PM) allele having 55–200 CGG•CCG-repeats in the 5’ UTR of the FMR1 gene. The mechanism of expansion is unknown....

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Detalhes bibliográficos
Main Authors: Entezam, A., Lokanga, A. R., Le, W., Hoffman, G., Usdin, K.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2951473/
https://ncbi.nlm.nih.gov/pubmed/20213777
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/humu.21237
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