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Potassium bromate, a potent DNA oxidizing agent, exacerbates germline repeat expansion in a Fragile X premutation mouse model
Tandem repeat expansion is responsible for the Repeat Expansion Diseases, a group of human genetic disorders that includes Fragile X syndrome. FXS results from expansion of a premutation (PM) allele having 55–200 CGG•CCG-repeats in the 5’ UTR of the FMR1 gene. The mechanism of expansion is unknown....
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| Главные авторы: | , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2010
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2951473/ https://ncbi.nlm.nih.gov/pubmed/20213777 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/humu.21237 |
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