Generation of a selective small molecule inhibitor of the CBP/p300 bromodomain for leukemia therapy

The histone acetyltransferases CBP/p300 are involved in recurrent leukemia-associated chromosomal translocations and are key regulators of cell growth. Therefore, efforts to generate inhibitors of CBP/p300 are of clinical value. We developed a specific and potent acetyl-lysine competitive protein-pr...

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Opis bibliograficzny
Wydane w:Cancer Res
Główni autorzy: Picaud, Sarah, Fedorov, Oleg, Thanasopoulou, Angeliki, Leonards, Katharina, Jones, Katherine, Meier, Julia, Olzscha, Heidi, Monteiro, Octovia, Martin, Sarah, Philpott, Martin, Tumber, Anthony, Filippakopoulos, Panagis, Yapp, Clarence, Wells, Christopher, Che, Ka Hing, Bannister, Andrew, Robson, Samuel, Kumar, Umesh, Parr, Nigel, Lee, Kevin, Lugo, Dave, Jeffrey, Philip, Taylor, Simon, Vecellio, Matteo L., Bountra, Chas, Brennan, Paul E., O’Mahony, Alison, Velichko, Sharlene, Müller, Susanne, Hay, Duncan, Daniels, Danette L., Urh, Marjeta, La Thangue, Nicholas B., Kouzarides, Tony, Prinjha, Rab, Schwaller, Jürg, Knapp, Stefan
Format: Artigo
Język:Inglês
Wydane: 2015
Hasła przedmiotowe:
Article
Dostęp online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4948672/
https://ncbi.nlm.nih.gov/pubmed/26552700
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-15-0236
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