HuR is required for NOX-1 but not NOX-4 regulation by inflammatory stimuli in vascular smooth muscle cells

OBJECTIVE: NOX-1 and NOX-4 are key enzymes responsible for reactive oxygen species (ROS) generation in vascular smooth muscle cells (VSMC). The RNA-binding protein HuR is implicated in post-transcriptional regulation of gene expression; however, its role regulating NOX is unknown. We investigated tr...

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Pubblicato in:J Hypertens
Autori principali: AGUADO, Andrea, FISCHER, Thierry, RODRÍGUEZ, Cristina, MANEA, Adrian, MARTÍNEZ-GONZÁLEZ, José, TOUYZ, Rhian M., HERNANZ, Raquel, ALONSO, M. Jesús, DIXON, Dan A., BRIONES, Ana M., SALAICES, Mercedes
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2016
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4947528/
https://ncbi.nlm.nih.gov/pubmed/26682942
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/HJH.0000000000000801
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