Structural and functional insights into IZUMO1 recognition by JUNO in mammalian fertilization

Sperm–egg fusion is the critical step in mammalian fertilization, and requires the interaction between IZUMO1 on the sperm surface and JUNO (also known as folate receptor (FR) 4 or IZUMO1R) on the egg surface. Whereas other FRs bind and uptake folates, JUNO binds IZUMO1 and establishes the cell–cell...

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Veröffentlicht in:Nat Commun
Hauptverfasser: Kato, Kazuki, Satouh, Yuhkoh, Nishimasu, Hiroshi, Kurabayashi, Arisa, Morita, Junko, Fujihara, Yoshitaka, Oji, Asami, Ishitani, Ryuichiro, Ikawa, Masahito, Nureki, Osamu
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2016
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4947182/
https://ncbi.nlm.nih.gov/pubmed/27416963
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms12198
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