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Sperm-borne phospholipase C zeta-1 ensures monospermic fertilization in mice
Sperm entry in mammalian oocytes triggers intracellular Ca(2+) oscillations that initiate resumption of the meiotic cell cycle and subsequent activations. Here, we show that phospholipase C zeta 1 (PLCζ1) is the long-sought sperm-borne oocyte activation factor (SOAF). Plcz1 gene knockout (KO) mouse...
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| Publicado no: | Sci Rep |
|---|---|
| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5778054/ https://ncbi.nlm.nih.gov/pubmed/29358633 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-19497-6 |
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