Structural and functional insights into IZUMO1 recognition by JUNO in mammalian fertilization

Sperm–egg fusion is the critical step in mammalian fertilization, and requires the interaction between IZUMO1 on the sperm surface and JUNO (also known as folate receptor (FR) 4 or IZUMO1R) on the egg surface. Whereas other FRs bind and uptake folates, JUNO binds IZUMO1 and establishes the cell–cell...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Kato, Kazuki, Satouh, Yuhkoh, Nishimasu, Hiroshi, Kurabayashi, Arisa, Morita, Junko, Fujihara, Yoshitaka, Oji, Asami, Ishitani, Ryuichiro, Ikawa, Masahito, Nureki, Osamu
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4947182/
https://ncbi.nlm.nih.gov/pubmed/27416963
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms12198
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