Structural and functional insights into IZUMO1 recognition by JUNO in mammalian fertilization

Sperm–egg fusion is the critical step in mammalian fertilization, and requires the interaction between IZUMO1 on the sperm surface and JUNO (also known as folate receptor (FR) 4 or IZUMO1R) on the egg surface. Whereas other FRs bind and uptake folates, JUNO binds IZUMO1 and establishes the cell–cell...

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Publicado en:Nat Commun
Main Authors: Kato, Kazuki, Satouh, Yuhkoh, Nishimasu, Hiroshi, Kurabayashi, Arisa, Morita, Junko, Fujihara, Yoshitaka, Oji, Asami, Ishitani, Ryuichiro, Ikawa, Masahito, Nureki, Osamu
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group 2016
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4947182/
https://ncbi.nlm.nih.gov/pubmed/27416963
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms12198
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