The secreted enzyme PM20D1 regulates lipidated amino acid uncouplers of mitochondria

Brown and beige adipocytes are specialized cells that express UCP1 and dissipate chemical energy as heat. These cells likely possess alternative UCP1-independent thermogenic mechanisms. Here we identify a secreted enzyme, peptidase M20 domain containing 1 (PM20D1), that is enriched in UCP1+ versus U...

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Udgivet i:Cell
Main Authors: Long, Jonathan Z., Svensson, Katrin J., Bateman, Leslie A., Lin, Hua, Kamenecka, Theodore, Lokurkar, Isha A., Lou, Jesse, Rao, Rajesh R., Chang, Mi Ra, Jedrychowski, Mark P., Paulo, Joao A., Gygi, Steven P., Griffin, Patrick R., Nomura, Daniel K., Spiegelman, Bruce M.
Format: Artigo
Sprog:Inglês
Udgivet: 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4947008/
https://ncbi.nlm.nih.gov/pubmed/27374330
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2016.05.071
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