Endothelin A receptor activation on mesangial cells initiates Alport glomerular disease

Recent work demonstrates that Alport glomerular disease is mediated through a biomechanical strain-sensitive activation of mesangial actin dynamics. This occurs through a Rac1/CDC42 cross-talk mechanism that results in the invasion of the sub-capillary spaces by mesangial filopodia. The filopodia de...

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Pubblicato in:Kidney Int
Autori principali: Dufek, Brianna, Meehan, Daniel, Delimont, Duane, Cheung, Linda, Gratton, Michael Anne, Phillips, Grady, Song, Wenping, Liu, Shiguang, Cosgrove, Dominic
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2016
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4946972/
https://ncbi.nlm.nih.gov/pubmed/27165837
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.kint.2016.02.018
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