NR2A and NR2B subunits differentially mediate MAP kinase signaling and mitochondrial morphology following excitotoxic insult

NMDA receptors are essential for neurotransmission and key mediators of synaptic signaling, but they can also trigger deleterious degenerative processes that lead to cell death. Growing evidence suggests that selective blockade of the heterogeneous subunits that comprise the NMDA receptor may enable...

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Publicado en:Neurochem Int
Autores principales: Choo, Anthony M., Geddes-Klein, Donna M., Hockenberry, Adam, Scarsella, David, Mesfin, Mahlet N., Singh, Pallab, Patel, Tapan P., Meaney, David F.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2012
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4946952/
https://ncbi.nlm.nih.gov/pubmed/22366650
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuint.2012.02.007
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