NR2A and NR2B subunits differentially mediate MAP kinase signaling and mitochondrial morphology following excitotoxic insult

NMDA receptors are essential for neurotransmission and key mediators of synaptic signaling, but they can also trigger deleterious degenerative processes that lead to cell death. Growing evidence suggests that selective blockade of the heterogeneous subunits that comprise the NMDA receptor may enable...

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Udgivet i:Neurochem Int
Main Authors: Choo, Anthony M., Geddes-Klein, Donna M., Hockenberry, Adam, Scarsella, David, Mesfin, Mahlet N., Singh, Pallab, Patel, Tapan P., Meaney, David F.
Format: Artigo
Sprog:Inglês
Udgivet: 2012
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4946952/
https://ncbi.nlm.nih.gov/pubmed/22366650
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuint.2012.02.007
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