Differential Requirement of the Extracellular Domain in Activation of Class B G Protein-coupled Receptors

G protein-coupled receptors (GPCRs) from the secretin-like (class B) family are key players in hormonal homeostasis and are important drug targets for the treatment of metabolic disorders and neuronal diseases. They consist of a large N-terminal extracellular domain (ECD) and a transmembrane domain...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:J Biol Chem
Prif Awduron: Zhao, Li-Hua, Yin, Yanting, Yang, Dehua, Liu, Bo, Hou, Li, Wang, Xiaoxi, Pal, Kuntal, Jiang, Yi, Feng, Yang, Cai, Xiaoqing, Dai, Antao, Liu, Mingyao, Wang, Ming-Wei, Melcher, Karsten, Xu, H. Eric
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Biochemistry and Molecular Biology 2016
Pynciau:
Membrane Biology
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4946928/
https://ncbi.nlm.nih.gov/pubmed/27226600
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.726620
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