Interferon β (IFN-β) Production during the Double-stranded RNA (dsRNA) Response in Hepatocytes Involves Coordinated and Feedforward Signaling through Toll-like Receptor 3 (TLR3), RNA-dependent Protein Kinase (PKR), Inducible Nitric Oxide Synthase (iNOS), and Src Protein

The sensing of double-stranded RNA (dsRNA) in the liver is important for antiviral defenses but can also contribute to sterile inflammation during liver injury. Hepatocytes are often the target of viral infection and are easily injured by inflammatory insults. Here we sought to establish the pathway...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Zhang, Liyong, Xiang, Wenpei, Wang, Guoliang, Yan, Zhengzheng, Zhu, Zhaowei, Guo, Zhong, Sengupta, Rajib, Chen, Alex F., Loughran, Patricia A., Lu, Ben, Wang, Qingde, Billiar, Timothy R.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2016
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4946926/
https://ncbi.nlm.nih.gov/pubmed/27226571
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.717942
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