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1,4-Diphenalkylpiperidines: A new scaffold for the design of potent inhibitors of the vesicular monoamine transporter-2

A series of 1,4-diphenalkylpiperidine analogs were synthesized and evaluated for their affinity and inhibitory potency at the [(3)H]dihydrotetrabenazine (DTBZ) binding site and [(3)H]dopamine (DA) uptake site on the vesicular monoamine transporter-2 (VMAT2). Results revealed that translocation of th...

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Dades bibliogràfiques
Publicat a:Bioorg Med Chem Lett
Autors principals: Nickell, Justin R., Culver, John P., Janganati, Venumadhav, Zheng, Guangrong, Dwoskin, Linda P., Crooks, Peter A.
Format: Artigo
Idioma:Inglês
Publicat: 2016
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4946565/
https://ncbi.nlm.nih.gov/pubmed/27212067
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2016.05.025
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