Decreased Ferroportin Promotes Myeloma Cell Growth and Osteoclast Differentiation

Iron homeostasis is disrupted in multiple myeloma, a difficult-to-cure plasma cell malignancy with lytic bone lesions. Here, we systematically analyzed iron gene expression signature and demonstrated that mRNA expression of iron exporter ferroportin (FPN1) is significantly downregulated in myeloma c...

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Pubblicato in:Cancer Res
Autori principali: Gu, Zhimin, Wang, He, Xia, Jiliang, Yang, Ye, Jin, Zhendong, Xu, Hongwei, Shi, Jumei, De Domenico, Ivana, Tricot, Guido, Zhan, Fenghuang
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2015
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4946247/
https://ncbi.nlm.nih.gov/pubmed/25855377
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-14-3804
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