Decreased Ferroportin Promotes Myeloma Cell Growth and Osteoclast Differentiation

Iron homeostasis is disrupted in multiple myeloma, a difficult-to-cure plasma cell malignancy with lytic bone lesions. Here, we systematically analyzed iron gene expression signature and demonstrated that mRNA expression of iron exporter ferroportin (FPN1) is significantly downregulated in myeloma c...

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Bibliografiske detaljer
Udgivet i:Cancer Res
Main Authors: Gu, Zhimin, Wang, He, Xia, Jiliang, Yang, Ye, Jin, Zhendong, Xu, Hongwei, Shi, Jumei, De Domenico, Ivana, Tricot, Guido, Zhan, Fenghuang
Format: Artigo
Sprog:Inglês
Udgivet: 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4946247/
https://ncbi.nlm.nih.gov/pubmed/25855377
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-14-3804
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