SSRI Augmentation by 5-Hydroxytryptophan Slow Release: Mouse Pharmacodynamic Proof of Concept

Drugs, notably SSRIs, that elevate brain extracellular 5-HT (5-HT(Ext)) are antidepressants. Unfortunately, most patients fail to remit. Multipronged clinical evidence suggests that elevating 5-HT(Ext) beyond the SSRI effect enhances antidepressant efficacy, but previous such drug strategies had pro...

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Pubblicato in:Neuropsychopharmacology
Autori principali: Jacobsen, Jacob PR, Rudder, Meghan L, Roberts, Wendy, Royer, Elizabeth L, Robinson, Taylor J, Oh, Adrianna, Spasojevic, Ivan, Sachs, Benjamin D, Caron, Marc G
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2016
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Original Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4946063/
https://ncbi.nlm.nih.gov/pubmed/26932820
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/npp.2016.35
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