SSRI Augmentation by 5-Hydroxytryptophan Slow Release: Mouse Pharmacodynamic Proof of Concept

Drugs, notably SSRIs, that elevate brain extracellular 5-HT (5-HT(Ext)) are antidepressants. Unfortunately, most patients fail to remit. Multipronged clinical evidence suggests that elevating 5-HT(Ext) beyond the SSRI effect enhances antidepressant efficacy, but previous such drug strategies had pro...

Full description

Saved in:
Bibliographic Details
Published in:Neuropsychopharmacology
Main Authors: Jacobsen, Jacob PR, Rudder, Meghan L, Roberts, Wendy, Royer, Elizabeth L, Robinson, Taylor J, Oh, Adrianna, Spasojevic, Ivan, Sachs, Benjamin D, Caron, Marc G
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2016
Subjects:
Original Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4946063/
https://ncbi.nlm.nih.gov/pubmed/26932820
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/npp.2016.35
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items