Slow-release delivery enhances the pharmacological properties of oral 5-hydroxytryptophan: mouse proof-of-concept

5-hydroxytryptophan (5-HTP) has shown therapeutic promise in a range of human CNS disorders. But native 5-HTP immediate release (IR) is poorly druggable, as rapid absorption causes rapid onset of adverse events, and rapid elimination causes fluctuating exposure. Recently, we reported that 5-HTP deli...

Full description

Saved in:
Bibliographic Details
Published in:Neuropsychopharmacology
Main Authors: Jacobsen, Jacob P. R., Oh, Adrianna, Bangle, Rachel, Roberts, Wendy L., Royer, Elizabeth L., Modesto, Nathan, Windermere, Sonora A., Yi, Zixuan, Vernon, Rebecca, Cajina, Manuel, Urs, Nikhil M., Snyder, Joshua C., Nicholls, Peter J., Sachs, Benjamin D., Caron, Marc G.
Format: Artigo
Language:Inglês
Published: Springer International Publishing 2019
Subjects:
Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6898594/
https://ncbi.nlm.nih.gov/pubmed/31035282
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41386-019-0400-1
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items