Slow-release delivery enhances the pharmacological properties of oral 5-hydroxytryptophan: mouse proof-of-concept

5-hydroxytryptophan (5-HTP) has shown therapeutic promise in a range of human CNS disorders. But native 5-HTP immediate release (IR) is poorly druggable, as rapid absorption causes rapid onset of adverse events, and rapid elimination causes fluctuating exposure. Recently, we reported that 5-HTP deli...

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書誌詳細
出版年:Neuropsychopharmacology
主要な著者: Jacobsen, Jacob P. R., Oh, Adrianna, Bangle, Rachel, Roberts, Wendy L., Royer, Elizabeth L., Modesto, Nathan, Windermere, Sonora A., Yi, Zixuan, Vernon, Rebecca, Cajina, Manuel, Urs, Nikhil M., Snyder, Joshua C., Nicholls, Peter J., Sachs, Benjamin D., Caron, Marc G.
フォーマット: Artigo
言語:Inglês
出版事項: Springer International Publishing 2019
主題:
Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC6898594/
https://ncbi.nlm.nih.gov/pubmed/31035282
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41386-019-0400-1
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