Potential Pitfalls of the Mx1-Cre System: Implications for Experimental Modeling of Normal and Malignant Hematopoiesis

Conditional knockout mice are commonly used to study the function of specific genes in hematopoiesis. Different promoters that drive Cre expression have been utilized, with the interferon-inducible Mx1-Cre still being the most commonly used “deleter strain” in experimental hematology. However, diffe...

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Udgivet i:Stem Cell Reports
Main Authors: Velasco-Hernandez, Talia, Säwén, Petter, Bryder, David, Cammenga, Jörg
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2016
Fag:
Report
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4945592/
https://ncbi.nlm.nih.gov/pubmed/27373927
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stemcr.2016.06.002
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