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Potential Pitfalls of the Mx1-Cre System: Implications for Experimental Modeling of Normal and Malignant Hematopoiesis

Conditional knockout mice are commonly used to study the function of specific genes in hematopoiesis. Different promoters that drive Cre expression have been utilized, with the interferon-inducible Mx1-Cre still being the most commonly used “deleter strain” in experimental hematology. However, diffe...

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Bibliografski detalji
Izdano u:Stem Cell Reports
Glavni autori: Velasco-Hernandez, Talia, Säwén, Petter, Bryder, David, Cammenga, Jörg
Format: Artigo
Jezik:Inglês
Izdano: Elsevier 2016
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4945592/
https://ncbi.nlm.nih.gov/pubmed/27373927
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stemcr.2016.06.002
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