Potential Pitfalls of the Mx1-Cre System: Implications for Experimental Modeling of Normal and Malignant Hematopoiesis

Conditional knockout mice are commonly used to study the function of specific genes in hematopoiesis. Different promoters that drive Cre expression have been utilized, with the interferon-inducible Mx1-Cre still being the most commonly used “deleter strain” in experimental hematology. However, diffe...

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發表在:Stem Cell Reports
Main Authors: Velasco-Hernandez, Talia, Säwén, Petter, Bryder, David, Cammenga, Jörg
格式: Artigo
語言:Inglês
出版: Elsevier 2016
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4945592/
https://ncbi.nlm.nih.gov/pubmed/27373927
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stemcr.2016.06.002
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