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Potential Pitfalls of the Mx1-Cre System: Implications for Experimental Modeling of Normal and Malignant Hematopoiesis

Conditional knockout mice are commonly used to study the function of specific genes in hematopoiesis. Different promoters that drive Cre expression have been utilized, with the interferon-inducible Mx1-Cre still being the most commonly used “deleter strain” in experimental hematology. However, diffe...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Stem Cell Reports
Prif Awduron: Velasco-Hernandez, Talia, Säwén, Petter, Bryder, David, Cammenga, Jörg
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Elsevier 2016
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4945592/
https://ncbi.nlm.nih.gov/pubmed/27373927
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stemcr.2016.06.002
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