Systemic delivery of IL-27 by an adeno-associated viral vector inhibits T cell-mediated colitis and induces multiple inhibitory pathways in T cells

IL-27 is a heterodimeric cytokine that is composed of two subunits, i.e., EBV-induced gene 3 and IL-27p28 (also known as IL-30). Although the role of endogenous IL-27 in the pathogenesis of autoimmune colitis, an experimental model of human inflammatory bowel disease, remains controversial, IL-27 lo...

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Podrobná bibliografie
Vydáno v:J Leukoc Biol
Hlavní autoři: Zhu, Xiaotong, Liu, Zhihao, Liu, Jin-Qing, Zhu, Jianmin, Zhang, Jianchao, Davis, Jonathan P., Chu, Jianhong, Yu, Jianhua, Zhou, Jie, Li, Ming-Song, Bai, Xue-Feng
Médium: Artigo
Jazyk:Inglês
Vydáno: Society for Leukocyte Biology 2016
Témata:
Inflammation, Extracellular Mediators, & Effector Molecules
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4945352/
https://ncbi.nlm.nih.gov/pubmed/27106672
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1189/jlb.3A1215-540R
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