Tyrosine kinase 2 promotes sepsis-associated lethality by facilitating production of interleukin-27

The aim of this study was to test the hypothesis that gene expression and release of IL-27 may be modulated by Tyk2. Macrophages derived from the peritoneum or bone marrow of C57BL/10SnJ (WT) mice produced abundant amounts of IL-27(p28) following TLR4 activation by LPS. In contrast, production of IL...

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Bibliografiske detaljer
Main Authors: Bosmann, Markus, Strobl, Birgit, Kichler, Nadia, Rigler, Doris, Grailer, Jamison J., Pache, Florence, Murray, Peter J., Müller, Mathias, Ward, Peter A.
Format: Artigo
Sprog:Inglês
Udgivet: Society for Leukocyte Biology 2014
Fag:
Inflammation, Extracellular Mediators, & Effector Molecules
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4056273/
https://ncbi.nlm.nih.gov/pubmed/24604832
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1189/jlb.3A1013-541R
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