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Tyrosine kinase 2 promotes sepsis-associated lethality by facilitating production of interleukin-27
The aim of this study was to test the hypothesis that gene expression and release of IL-27 may be modulated by Tyk2. Macrophages derived from the peritoneum or bone marrow of C57BL/10SnJ (WT) mice produced abundant amounts of IL-27(p28) following TLR4 activation by LPS. In contrast, production of IL...
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| Autori principali: | , , , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Society for Leukocyte Biology
2014
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4056273/ https://ncbi.nlm.nih.gov/pubmed/24604832 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1189/jlb.3A1013-541R |
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