The Molecular Switching Mechanism at the Conserved D(E)RY Motif in Class-A GPCRs

The disruption of ionic and H-bond interactions between the cytosolic ends of transmembrane helices TM3 and TM6 of class-A (rhodopsin-like) G protein-coupled receptors (GPCRs) is a hallmark for their activation by chemical or physical stimuli. In the bovine photoreceptor rhodopsin, this is accompani...

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Bibliografiske detaljer
Udgivet i:Biophys J
Main Authors: Sandoval, Angelica, Eichler, Stefanie, Madathil, Sineej, Reeves, Philip J., Fahmy, Karim, Böckmann, Rainer A.
Format: Artigo
Sprog:Inglês
Udgivet: The Biophysical Society 2016
Fag:
Channels and Transporters
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4945304/
https://ncbi.nlm.nih.gov/pubmed/27410736
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2016.06.004
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