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Exploiting DNA repair defects for novel cancer therapies

Most human tumors accumulate a multitude of genetic changes due to defects in the DNA damage response. Recently, small-molecule inhibitors have been developed that target cells with specific DNA repair defects, providing hope for precision treatment of such tumors. Here we discuss the rationale behi...

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Dades bibliogràfiques
Publicat a:Mol Biol Cell
Autors principals: van Gent, Dik C., Kanaar, Roland
Format: Artigo
Idioma:Inglês
Publicat: The American Society for Cell Biology 2016
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4945134/
https://ncbi.nlm.nih.gov/pubmed/27418635
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E15-10-0698
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