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DDX11 loss causes replication stress and pharmacologically exploitable DNA repair defects
DDX11 encodes an iron–sulfur cluster DNA helicase required for development, mutated, and overexpressed in cancers. Here, we show that loss of DDX11 causes replication stress and sensitizes cancer cells to DNA damaging agents, including poly ADP ribose polymerase (PARP) inhibitors and platinum drugs....
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2021
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8092582/ https://ncbi.nlm.nih.gov/pubmed/33879618 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2024258118 |
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