Loss of CHD1 causes DNA repair defects and enhances prostate cancer therapeutic responsiveness

The CHD1 gene, encoding the chromo‐domain helicase DNA‐binding protein‐1, is one of the most frequently deleted genes in prostate cancer. Here, we examined the role of CHD1 in DNA double‐strand break (DSB) repair in prostate cancer cells. We show that CHD1 is required for the recruitment of CtIP to...

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Detalhes bibliográficos
Publicado no:EMBO Rep
Main Authors: Kari, Vijayalakshmi, Mansour, Wael Yassin, Raul, Sanjay Kumar, Baumgart, Simon J, Mund, Andreas, Grade, Marian, Sirma, Hüseyin, Simon, Ronald, Will, Hans, Dobbelstein, Matthias, Dikomey, Ekkehard, Johnsen, Steven A
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2016
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5090703/
https://ncbi.nlm.nih.gov/pubmed/27596623
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embr.201642352
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